Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal

Plotnick GD, Corretti MC, Vogel RA, Hesslink R Jr, Wise JA; May 2003


It has been previously established that ingestion of a high-fat meal impairs flow-mediated vasodilation of the brachial artery for at least four hours.


The goal of this study was to determine whether the administration of two different formulations of an encapsulated juice powder concentrate rich in a range of phytochemicals could ameliorate the deleterious effect of a high-fat meal on vasodilation.


In this randomized, double-blind placebo-controlled trial, healthy volunteers were assigned to take either: 1. A fruit and vegetable juice powder concentrate (FV; Juice Plus+®) 2. A fruit, vegetable and berry juice powder concentrate (FVB; Juice Plus®), or 3. Placebo for 28 days.  

Vasoconstriction was measured using the flow-mediated brachial artery reactivity test (BART) at baseline, day 21, and day 28, both before and after a high-fat (50 grams) meal. Serum nitrate/nitrite concentrations were measured at baseline and at 4 weeks.


On both day 21 and day 28, the detrimental effect of a high-fat meal on vasodilation was significantly decreased in both intervention groups compared to the placebo group. For example, on day 28, those taking placebo suffered a 38% decrease in vasodilation after the high-fat meal, while those taking FV experienced a 17% decrease. Adding Berry Blend to the regimen further improved results: these volunteers had less than a 2% drop in vasodilation. There was a trend for serum nitrate/nitrite levels to increase in both supplementation groups.  


In healthy volunteers, four weeks of daily supplementation with a fruit-and-vegetable concentrate, with or without an adjunctive complex phytochemical supplement, blunts the detrimental effect of a high-fat meal on flow-mediated brachial artery vasodilation—even when the supplement is not administered with the meal—and increases the combined serum nitrite/nitrate concentration.

PubMed link:


PDF summary: 
View PDF